RESUMO
Background: Preeclampsia is a common obstetrical problem affecting 5-10% of pregnant females. The objective of this study was to determine and compare liver function tests in primigravidas in second and third trimesters of normal pregnancy and preeclampsia
Methods: A cross-sectional comparative study was conducted that included 100 subjects aged 15-40 years with normal pregnancy, and preeclamptic primigravidas of second and third trimester. Their liver function tests were carried out and compared among the study groups
Results: The mean age of the subjects was 25.92+/-5.56 years, mean systolic BP was 136.3+/-24.623 mmHg, mean diastolic blood pressure was 87.8+/-15.736 mmHg. There were statistically significant differences in AST, ALT, ALP, and serum albumin among cases and controls of both 2[nd] and 3[rd] trimester [p<0.05]. However, serum total bilirubin among preeclamptics of 2[nd] and 3[rd] trimesters, and also between controls and preeclamptics of 3[rd] trimester was significantly increased [p<0.05]. Serum AST and ALT were significantly decreased among controls of 3[rd] trimesters compared to 2[nd] trimester while ALP was significantly increased in 3[rd] trimester controls compared to 2[nd] trimester controls. Serum albumin was significantly decreased in both 2[nd] and 3[rd] trimester preeclamptics compared to controls
Conclusion: Serum AST, ALP, and bilirubin was significantly increased in 3[rd] trimester preeclamptics compared to 2[nd] trimester preeclamptics
RESUMO
Background: Hepatic encephalopathy [HE] involves neuropsychiatric dysfunction as a result of metabolic disturbance. The objective of the study was to determine and compare grades of hepatic encephalopathy in patients of viral hepatitis B, C, and co-infection
Methods: A cross-sectional study was designed which included seventy five patients of chronic HBV, HCV, and co-infection of either sex, aged 35 years or above. The patients were equally divided into 3 groups. Hepatic encephalopathy was classified into four grades based on the West Haven classification
Results: Out of the 75 subjects, 51 [68.0%] were males and 24 [32.0%] were females. The Mean age was 44.69+/-7.423 years. Grade I hepatic encephalopathy was a significant feature of both chronic HCV and co-infection groups. The development of grade II encephalopathy was more marked in chronic HBV group, while grade III encephalopathy was more frequent in chronic HCV group. However, frequency distribution of grade IV encephalopathy remained same in all groups
Conclusion: The study concluded that progression of encephalopathy was not more marked in co-infection group. In fact, hepatic encephalopathy equally developed in study groups
RESUMO
Background: Chronic infection with either Hepatitis B virus [HBV] or Hepatitis C virus [HCV] represents one of the major causes of chronic liver disease [CLD] globally. The objective of this study was to compare clinical features of CLD produced by chronic viral hepatitis B, C, and co-infection
Methods: A cross-sectional study was designed which included 75 patients of chronic HBV, HCV, and co-infection, aged 35 years or above, of either sex. The patients were equally divided into 3 groups
Results: Out of the 75 subjects, 51 [68%] were males and 24 [32%] were females. The mean age was 44.69+/-7.423 years. The relevant clinical features like fever, anorexia, and vomiting were more marked in chronic HBV group. However, splenomegaly as well as easily and poorly controlled ascites was distributed with same frequency in chronic HCV and co-infection groups. Breathlessness was equally frequent in chronic HBV and HCV groups, while hematemesis and melena were frequent in chronic HBV and co-infection groups. The frequency distribution of jaundice was more marked in co-infection group only
Conclusion: The clinical features were not more prevalent in co-infection group. The distribution of some features like breathlessness was same in two groups